ea0011oc4 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006
Cooray SN
, Chapple JP
, Metherell LA
, Cheetham ME
, Clark AJL
Familial Glucocorticoid Deficiency type 2 (patients with normal MC2R) is associated with mutations in the MRAP (Melanocortin Receptor Accessory Protein) gene. In order to investigate the function of this novel single transmembrane domain protein, CHO and SKN-SH cells were transfected with MRAP-FLAG and/or MC2R-GFP constructs and imaged using confocal microscopy. Although the MC2R-GFP failed to be expressed at the cell surface when transfected alone, it was found to be expresse...